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Initial in vivo studies with a polymer-based MR-compatible guide wire.

Ralf Mekle1, Michael O Zenge, Mark E Ladd

  • 1Division of MR Physics, Department of Medical Radiology, University Hospital Basel, Basel, Switzerland. ralf.mekle@epfl.ch

Journal of Vascular and Interventional Radiology : JVIR
|August 25, 2009
PubMed
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A new polymer-based, magnetic resonance imaging-compatible guide wire shows potential for guiding peripheral endovascular procedures. Near-real-time visualization was achieved in swine, aiding future human applications.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging

Background:

  • Magnetic resonance (MR) imaging offers excellent soft-tissue contrast for endovascular interventions.
  • Accurate navigation of guide wires is crucial for MR-guided procedures.
  • Existing guide wires may lack compatibility or visibility within MR environments.

Purpose of the Study:

  • To evaluate a novel polymer-based, MR imaging-compatible guide wire.
  • To assess its utility in MR-guided endovascular interventions, specifically peripheral MR angiography.
  • To develop and test a device tracking method for this application.

Main Methods:

  • Development of a passive device tracking method for peripheral MR angiography.
  • In vivo testing of the MR-compatible guide wire in swine.

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  • Near-real-time visualization of the guide wire in major arteries and the heart.

    • Main Results:

    • Successful near-real-time visualization of the guide wire was achieved in vivo.
    • The guide wire demonstrated compatibility and visibility within the MR environment.
    • The tracking method was effective under peripheral MR angiography conditions.

    Conclusions:

    • The new polymer-based, MR-compatible guide wire shows significant promise for MR-guided endovascular interventions.
    • It facilitates visualization crucial for interventional peripheral MR angiography.
    • This technology could enhance the safety and efficacy of future human procedures.