Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The antiplatelet activity of 6-piperazinyl-purine analogues bearing nitrate esters is determined by the length of the carbon side chain.

European journal of pharmacology·2026
Same author

Consensus on Aggregometry for platelet function testing in thrombocytopenic patients: Communication from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2026
Same author

A 25-year evaluation of direct local international normalized ratio calibration of the Owren type prothrombin time method in Sweden.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Bariatric surgery improves fibrinolysis in individuals with obesity with and without concomitant type 2 diabetes.

Clinical nutrition (Edinburgh, Scotland)·2026
Same author

Practices in platelet production: A Nordic perspective (2018-2022).

Vox sanguinis·2025
Same author

Biomarkers of in vivo platelet activation in coronary artery disease: a systematic review and meta-analysis: communication from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2025

Related Experiment Video

Updated: Jun 20, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Methods for evaluation of platelet function.

Tomas L Lindahl1, Sofia Ramström

  • 1Department of Clinical and Experimental Medicine, University of Linköping, Sweden. Tomas.lindahl@lio.se

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|August 25, 2009
PubMed
Summary
This summary is machine-generated.

Platelet function tests assess various aspects of platelet activity in hemostasis. A single test cannot capture all platelet functions, and clinical studies on platelet concentrate analysis are lacking.

More Related Videos

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Related Experiment Videos

Last Updated: Jun 20, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Hematology
  • Hemostasis
  • Platelet Biology

Background:

  • Platelets play a crucial role in hemostasis.
  • Numerous platelet function tests exist, reflecting their complex role.
  • No single test fully encompasses all platelet functions.

Purpose of the Study:

  • To review the landscape of platelet function tests.
  • To highlight the limitations of single-test approaches.
  • To identify the need for further clinical studies on platelet concentrates.

Main Methods:

  • Review of existing literature on platelet function tests.
  • Categorization of tests based on the aspect of platelet function assessed (e.g., aggregation, swelling, adhesion, coagulation).
  • Discussion of the clinical utility and limitations of current assays.

Main Results:

  • A wide array of platelet function tests are available, including aggregometry, hypotonic shock response, and thromboelastography.
  • Each test measures specific platelet activities, such as aggregation, swelling, adhesion, or coagulation.
  • There is a general lack of clinical studies demonstrating the predictive value of analyzing platelet concentrates.

Conclusions:

  • The complexity of platelet function necessitates multiple testing modalities.
  • Current diagnostic approaches do not offer a comprehensive assessment of platelet activity.
  • Further clinical research is required to establish the predictive value of platelet concentrate analysis in clinical practice.