Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antibiotic Selection

Antibiotic Selection

Bacterial Phylum Actinobacteria

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...

Development of Antibiotic Resistance

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

Acute Pyelonephritis I: Introduction

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Microbial Interactions: Competition

Microbial Interactions: Competition

Microbial competition is an ecological interaction in which microorganisms vie for limited resources within shared environments. These resources may include nutrients, space, or light, depending on the system. The intensity and outcome of competition are influenced by the environmental context, such as nutrient availability, spatial constraints, and the diversity of microbial species present. These competitive interactions significantly influence the structure, function, and resilience of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Great oaks from little acorns grow-21 years of CMI.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016

Same author

Direct detection of Clostridium difficile 027 in diarrhoeal stool samples.

The Journal of hospital infection·2011

Same author

Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase.

The Journal of hospital infection·2011

Same author

Novel genetic context of multiple bla OXA-58 genes in Acinetobacter genospecies 3.

The Journal of antimicrobial chemotherapy·2010

Same author

OXA-51-like beta-lactamases and their association with particular epidemic lineages of Acinetobacter baumannii.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2008

Same author

Genetic diversity of carbapenem-resistant isolates of Acinetobacter baumannii in Europe.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2007

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Acinetobacter: an old friend, but a new enemy.

¹Department of Clinical Microbiology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham NG7 2UH, UK. Kevin.Towner@nuh.nhs.uk

The Journal of Hospital Infection

|August 25, 2009

Summary

Acinetobacter baumannii is a growing hospital-acquired infection threat, especially multidrug-resistant strains. Enhanced infection control and antibiotic stewardship are crucial to combat escalating outbreaks in healthcare settings.

More Related Videos

Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Published on: August 4, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Characterizing Multidrug Efflux Systems in Acinetobacter baumannii Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System

Published on: January 5, 2024

Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Quantification, Viability Assessment, and Visualization Strategies for Acinetobacter Biofilms

Published on: August 4, 2023

Area of Science:

Medical Microbiology
Infectious Diseases
Hospital Epidemiology

Background:

Acinetobacter emerged as a significant nosocomial pathogen in the late 1970s, linked to increased broad-spectrum antibiotic use.
Clinically relevant Acinetobacter isolates, primarily Acinetobacter baumannii, frequently cause infections in intensive care, burns, and high-dependency units.
Outbreaks of epidemic strains of Acinetobacter baumannii are common in these units, affecting severely ill patients.

Purpose of the Study:

To highlight the escalating problem of multidrug-resistant Acinetobacter baumannii (MDR-AB) infections in healthcare settings.
To discuss the challenges in treating infections caused by these resistant strains, including limited therapeutic options.
To emphasize the importance of infection control and prevention strategies in managing Acinetobacter outbreaks.

Main Methods:

Review of clinical observations and epidemiological data regarding Acinetobacter infections.
Analysis of antimicrobial resistance patterns, particularly carbapenem resistance in Acinetobacter baumannii.
Evaluation of current infection control guidelines and their effectiveness.

Main Results:

Increasing global reports of Acinetobacter baumannii isolates resistant to all conventional antimicrobial agents.
Limited clinical data supporting the efficacy of newer agents like tigecycline against multidrug-resistant strains.
Persistent challenges in preventing and controlling outbreaks despite adherence to infection control measures.

Conclusions:

Multidrug-resistant Acinetobacter baumannii poses a significant and escalating threat in healthcare facilities worldwide.
Effective management requires robust antibiotic stewardship, stringent infection control, and improved disinfection protocols.
Further research is needed to develop and validate new therapeutic strategies against these challenging pathogens.