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Updated: Jun 20, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
[Eosinophilic esophagitis: report of three cases]
Carmen Gloria González F1, Javiera Torres, Ricardo Molina U
1Departamento de Pediatría, Pontificia Universidad Católica de Chile, Santiago, Chile.
Revista Medica De Chile
|August 25, 2009
Summary
Eosinophilic esophagitis (EE) presents with reflux and dysphagia unresponsive to antacids. Early diagnosis in children and adults with allergy history is crucial for effective treatment.
Area of Science:
- Gastroenterology
- Immunology
- Pediatrics
Background:
- Eosinophilic esophagitis (EE) is an idiopathic esophageal disease.
- Symptoms include reflux and dysphagia, often unresponsive to antacids.
- EE predominantly affects young males with a history of atopy, asthma, and allergies.
Observation:
- Three male pediatric patients (10, 14, 15 years) presented with dysphagia.
- Two patients experienced chest pain due to esophageal spasm.
- Endoscopic findings varied, including leukoplakia and stenosis requiring dilatation.
Findings:
- All patients exhibited abnormal immune study results (prick test or IgE levels).
- Treatment involved dietary changes, acid suppression, and leukotriene inhibitors.
- Satisfactory clinical, endoscopic, and histological responses were observed.
Implications:
- EE should be suspected in pediatric and adult patients with esophageal symptoms.
- A personal or family history of allergy and asthma is a key indicator.
- Multifaceted treatment approaches yield positive outcomes in EE management.
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