Related Experiment Videos
sTNFR-1 is an early inflammatory marker in community versus institutionalized elderly women
Fernanda Matos Coelho1, F M S Narciso, D M G Oliveira
1Laboratório da Dor e Inflamação em Reabilitação Sala 2102-A., Departamento de Fisioterapia da Escola de Educação Física, Fisioterapia e Terapia, Ocupacional, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil. fematoscoelho@gmail.com
Objective And Design:
To evaluate plasma sTNFR-1 and IL-6 levels and correlate with hand grip in the institutionalized and community living Brazilian elderly.
Material:
A convenience sample of 110 elderly women (71.17 + or - 7.44 years) was selected. Plasma sTNFR-1 and IL-6 levels were measured by ELISA. For the measurement of hand grip, a JAMAR dynamometer was used.
Results:
Plasma concentrations of inflammatory markers were significantly higher in institutionalized elderly (sTNFR-1: 479 + or - 22 pg/mL; IL-6: 6.3 + or - 0.8 pg/mL) than in community-dwelling elderly (sTNFR-1: 329 + or - 24 pg/mL; IL-6: 2.5 + or - 0.4 pg/mL; P < 0.0001). Institutionalized elderly had reduced hand grip (15 + or - 0.8 Kgf) in comparison to community dwelling elderly (23 + or - 0.6 Kgf; P < 0.05). When individuals were subdivided in age groups, sTNFR-1 was higher in community dwelling versus institutionalized elderly in the 60-70 age range.
Conclusions:
Our results demonstrate that being institutionalized has an impact on levels of inflammatory markers.
