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Updated: Jun 20, 2026
Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies
Published on: December 15, 2014
Reproducible and persistent weakness in adult rats after surgical resection of motor cortex: evaluation with limb
Do-Hun Lee1, Seok Ho Hong, Seung-Ki Kim
1Department of Neurosurgery, Seoul National University College of Medicine, 103 Daehang-no, Jongno-gu, Seoul 110-744, Korea.
Object:
The purpose of this study was to develop a new rat model for surgical brain injury with motor weakness and to find an adequate behavior test for the application of the model.
Methods:
Thirty rats were divided into three groups: craniectomy (n = 10), durotomy (n = 10), and corticectomy (n = 10) groups. The coordinates of the three points from the bregma (coordinate A = +4,+1, B = -2,+1, and C = +4,+6). We evaluated right limb motor performance by the modified limb placement test and the cylinder test.
Conclusion:
Persistent motor weakness was observed for 2 months in the corticectomy group by the limb placement test, whereas the cylinder test could not detect the weakness. We established a reproducible and persistent rat brain injury model and found that the modified limb placement test is sensitive enough to evaluate residual subtle weakness in this model.
