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Soluble intercellular adhesion molecule-1 and E-selectin in patients with asthma exacerbation
Mahdi Bijanzadeh1, Nallur B Ramachandra, P A Mahesh
1Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore, 570 006, Karnataka, India.
Lung
|August 25, 2009
Summary
Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) were elevated in asthma patients compared to healthy controls. However, most asthma patients had sICAM-1 and sE-selectin levels within the normal range, questioning their utility as standalone markers.
Area of Science:
- Immunology
- Biochemistry
- Clinical Medicine
Background:
- Soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) are implicated in inflammatory cell recruitment.
- These molecules are potential biomarkers for inflammatory diseases like asthma.
Purpose of the Study:
- To measure sICAM-1 and sE-selectin levels during acute asthma attacks in adults and children.
- To establish normal reference ranges (95th percentile) for these markers in healthy individuals.
Main Methods:
- Serum samples from 120 asthma patients (40 severe, 80 moderate-severe) and 50 healthy controls were analyzed.
- Enzyme-linked immunosorbent assay (ELISA) was used to quantify sICAM-1 and sE-selectin levels.
Main Results:
- sICAM-1 levels were significantly higher in asthma patients compared to healthy controls (P < 0.001).
- No significant difference in sE-selectin levels was found between asthma patients and controls (P = 0.778).
- Despite elevated mean levels, 88.3% of asthma patients had sICAM-1 and 98.5% had sE-selectin within the established normal ranges.
Conclusions:
- Elevated mean sICAM-1 levels suggest a role in asthma pathophysiology.
- The high percentage of patients with normal levels indicates that sICAM-1 and sE-selectin may not be reliable markers for acute asthma attacks without individual baseline comparisons.
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