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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Optically-guided frameless linac-based radiosurgery for brain metastases: clinical experience
Sameer K Nath1, Joshua D Lawson, Jia-Zhu Wang
1Department of Radiation Oncology, Rebecca and John Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, CA 92093-0843, USA. sameerknath@gmail.com
Journal of Neuro-Oncology
|August 25, 2009
Summary
Frameless stereotactic radiosurgery (SRS) using optical guidance offers effective treatment for brain metastases, achieving 76% local control at 12 months. This convenient technique shows promise for managing brain metastases.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Physics
Background:
- Brain metastases require effective treatment strategies.
- Stereotactic radiosurgery (SRS) is a key modality.
- Frameless SRS offers potential advantages over traditional methods.
Purpose of the Study:
- To evaluate the clinical outcomes of optically-guided linear accelerator (linac)-based frameless SRS for brain metastases.
- To assess local control, survival, and adverse events.
Main Methods:
- Sixty-five patients with 204 brain metastases were treated between 2005-2008.
- Frameless SRS utilized an optically-guided bite-block system.
- Dose ranged from 14-22 Gy in a single fraction, with follow-up every 2-4 months.
Main Results:
- Median follow-up was 6.2 months; 12-month actuarial survival was 40%.
- 12-month local control was 76% (119/135 lesions).
- Tumors ≤2 cm had significantly better local control (81% vs. 36%, P=0.017).
Conclusions:
- Optically-guided linac-based frameless SRS provides favorable clinical outcomes for brain metastases.
- The technique is convenient and suitable for hypofractionated radiotherapy.
- Frameless SRS is poised to play a significant role in managing brain metastases.
