Predicting of Nano Cerium/Hydroxyapatite Efficiency Against γ- Irradiation Induced Heart Failure in Albino Rats

Area of Science:

• Biomedical Engineering
• Materials Science
• Radiology

Background:

• Radiation therapy can cause significant cardiac damage.
• Developing effective radioprotective agents is crucial for patient safety.
• Nanomaterials offer potential therapeutic advantages.

Purpose of the Study:

• To investigate the therapeutic potential of nano cerium hydroxyapatite (nCe/HAp) against gamma-irradiation-induced cardiac failure.
• To evaluate the impact of nCe/HAp on oxidative stress and cardiac biomarkers.
• To assess the immunomodulatory effects of nCe/HAp in irradiated rats.

Main Methods:

• Cardiac failure was induced in male rats using 9 Gy gamma radiation.
• Nano cerium hydroxyapatite (nCe/HAp) was administered intravenously at 50 mg/kg.
• Oxidative status, cardiac enzymes (cTnI, CK, CK-MB, LDH), and immune markers (NF-kB, TNF-α, IL-6, CRP) were measured.
• Histopathological analysis of heart tissue was performed.

Main Results:

• nCe/HAp significantly increased antioxidant levels (GSH, SOD).
• Treatment with nCe/HAp markedly reduced cardiac enzyme levels (cTnI, CK, CK-MB, LDH) and inflammatory markers (NF-kB).
• Histopathological examination supported the protective effects of nCe/HAp against radiation-induced heart damage.

Conclusions:

• Nano cerium hydroxyapatite (nCe/HAp) demonstrates significant radioprotective efficacy against cardiac failure.
• nCe/HAp mitigates oxidative stress and inflammation, preserving cardiac function post-irradiation.
• Ce/HAp nanocomposites show promise as therapeutic agents for mitigating radiation-induced cardiotoxicity.