Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 20, 2026

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

FDDNP binding using MR derived cortical surface maps.

H D Protas1, S-C Huang, V Kepe

  • 1Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 10833 Le Conte Ave., Los Angeles, CA 90095, USA. hprotas@ucla.edu

Neuroimage
|August 26, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the Editor: First Experiences with Amyloid-Related Imaging Abnormalities - Yet without Imaging that Can Rule Out Cerebral Injury or Monitor Efficacy of Recommended Management.

The journal of prevention of Alzheimer's disease·2024
Same author

MRI Monitoring of Anti-Alzheimer Therapy Amyloid-Related Imaging Abnormalities: Due Diligence or Overkill?

AJNR. American journal of neuroradiology·2022
Same author

Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis.

Journal of internal medicine·2021
Same author

Gene expression and linkage analysis implicate CBLB as a mediator of rituximab resistance.

The pharmacogenomics journal·2017
Same author

Assessment of dementia risk in aging adults using both FDG-PET and FDDNP-PET imaging.

International journal of geriatric psychiatry·2012
Same author

Early diagnosis of Alzheimer's disease: update on combining genetic and brain-imaging measures.

Dialogues in clinical neuroscience·2011
Same journal

Decoding neuronal criticality firing patterns for large brain based EEG models.

NeuroImage·2026
Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
See all related articles

This study quantitatively assessed brain imaging patterns of beta-amyloid and tau tangles in Alzheimer's disease (AD). Corrected imaging revealed spatial patterns consistent with known AD pathology, aiding early diagnosis.

Area of Science:

  • Neuroimaging
  • Molecular Imaging
  • Neuropathology

Background:

  • Alzheimer's disease (AD) is characterized by beta-amyloid and neurofibrillary tangles.
  • Accurate in vivo quantification of these pathologies is crucial for understanding disease progression.

Purpose of the Study:

  • To quantitatively assess the cortical pattern of FDDNP binding to beta-amyloid and neurofibrillary tangles.
  • To create MR-derived cortical maps of FDDNP binding.
  • To correct FDDNP PET images for movement and partial volume (PV) and optimize kernel size.

Main Methods:

  • FDDNP DVR PET images from 23 subjects (AD, MCI, controls) were analyzed using Logan analysis with cerebellum as reference.
  • Hemispheric cortical surface models were extracted from MRI and co-registered with PET data.

More Related Videos

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
09:36

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Published on: March 23, 2022

Related Experiment Videos

Last Updated: Jun 20, 2026

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
09:36

In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Published on: March 23, 2022

  • Cortical maps underwent PV correction and discriminant analysis to differentiate disease states.

    • Main Results:

    • Movement and PV corrected FDDNP DVR cortical surfaces showed reduced hemispheric asymmetry.
    • An optimal kernel size of 9 mm was determined.
    • The corrected FDDNP DVR cortical surface map displayed spatial patterns aligning with known AD pathological progression.

    Conclusions:

    • Movement and PV correction, along with optimized kernel size, enable sensitive statistical analysis of FDDNP distribution.
    • This approach confirms known AD pathology patterns in the living brain, correlating with cognitive decline.
    • The findings support the use of advanced PET imaging techniques for early detection and monitoring of AD pathology.