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Interventricular mechanical dyssynchrony: quantification with velocity-encoded MR imaging.

Kai Muellerleile1, Loant Baholli, Michael Groth

  • 1Center for Cardiology and Cardiovascular Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. ka.muellerleile@uke.de

Radiology
|August 26, 2009
PubMed
Summary
This summary is machine-generated.

Velocity-encoded MRI accurately quantifies interventricular mechanical dyssynchrony (IVMD), matching echocardiography. This method effectively identifies potential responders for cardiac resynchronization therapy (CRT).

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Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Heart Failure Management

Background:

  • Interventricular mechanical dyssynchrony (IVMD) impacts heart failure outcomes.
  • Cardiac resynchronization therapy (CRT) is a treatment for heart failure with dyssynchrony.
  • Accurate IVMD assessment is crucial for predicting CRT response.

Purpose of the Study:

  • To compare velocity-encoded (VENC) magnetic resonance (MR) imaging with pulsed-wave echocardiography (PW-ECHO) for IVMD quantification.
  • To assess the utility of VENC MR imaging in predicting CRT response.

Main Methods:

  • 45 heart failure patients with reduced ejection fraction underwent VENC MR imaging and PW-ECHO.
  • IVMD was defined as the time difference between aortic and pulmonary flow onsets.
  • Statistical analyses included intraclass correlation, Spearman correlation, Bland-Altman, and Cohen kappa.

Main Results:

  • VENC MR imaging demonstrated excellent inter- and intraobserver agreement for IVMD measurements.
  • Strong correlation and agreement were found between VENC MR imaging and PW-ECHO for IVMD quantification.
  • Excellent agreement was observed in identifying potential CRT responders using VENC MR imaging compared to PW-ECHO.

Conclusions:

  • VENC MR imaging provides measurements of IVMD equivalent to PW-ECHO.
  • VENC MR imaging is a reliable tool for identifying patients who may benefit from CRT.