Dynamic compression of the left main coronary artery by the left atrium
Robin A Ducas1, Davinder S Jassal, Iain D C Kirkpatrick
1Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. jducas@sbgh.mb.ca
Insights
Severe mitral regurgitation caused dynamic compression of the left main coronary artery due to enlarged left atrium. This led to heart failure symptoms and angina in a 67-year-old woman.
Area of Science:
- Cardiology
- Cardiac Imaging
- Vascular Physiology
Background:
- A 67-year-old woman presented with worsening heart failure and angina.
- Her medical history included severe mitral valve regurgitation.
Observation:
- Coronary angiography showed dynamic systolic flow limitation in the left main (LM) coronary artery without atherosclerotic disease.
- Intravascular ultrasound revealed systolic LM coronary artery distortion and cross-sectional area reduction.
- Cardiac CT demonstrated left atrial enlargement compressing the LM coronary artery.
Findings:
- The patient was diagnosed with dynamic compression of the LM coronary artery.
- This compression was secondary to systolic left atrial enlargement caused by mitral regurgitation.
Implications:
- This case highlights a rare cause of coronary artery compression.
- It underscores the importance of considering dynamic mechanical factors in coronary artery disease diagnosis.
- Accurate diagnosis requires integrated interpretation of angiography, intravascular ultrasound, and cardiac CT.
Abstract:
We report a case of a 67-year-old woman with a past medical history of severe mitral valve regurgitation with worsening congestive heart failure symptoms and angina. Coronary angiography revealed dynamic limitation of contrast flow during systole in the left main (LM) coronary artery, but no evidence of obstructive atherosclerotic disease. Intravascular ultrasound demonstrated a dynamic distortion and reduction of the LM coronary artery cross sectional area during systole. Cardiac computed tomography demonstrated left atrial enlargement with extrinsic distortion and compression of the LM coronary artery. A diagnosis was made of dynamic compression of the LM coronary artery secondary to systolic left atrial enlargement resulting from mitral regurgitation.
Related Concept Videos
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Physiology of the Heart: The Cardiac Cycle
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
Mitral Stenosis I: Introduction
Chambers of the Heart
Deoxygenated blood from the body is received in the right...
Cardiac Catheterization III: Left Heart Catheterization
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...

