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Updated: Jun 20, 2026

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure
Published on: May 15, 2020
The rabbit as an animal model for experimental surgery
Mônica Diuana Calasans-Maia1, Maria Lucia Monteiro, Fábio Oliveira Ascoli
1Cell Therapy Center, University Hospital Antonio Pedro, Fluminense Federal University, Niteroi, RJ, Brazil. monicacalasans@terra.com.br
Abstract:
The white New Zealand rabbit (Oryctolagus cuniculus) is frequently used as a model for in vivo studies. However, information on precautions when using this animal as an experimental model is limited. This review of the literature covers the gamut from the selection of the animal model all the way to its death, and describes procedures for transporting, raising, breeding, housing, administering anesthesia and handling so as to rationalize the utilization of this species while exploiting its unique characteristics. Based upon the literature and our own experience with white New Zealand rabbits, we conclude that the rabbit is an adequate model for experimental surgery.

