Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Normalization method for relative cerebral blood flow influences sex and cognitive status effects in nondemented older adults.

Brain imaging and behavior·2026

Same author

Beyond proximity: how food quality in dollar and grocery stores influences health.

BMC public health·2026

Same author

Association of Preoperative Posterior Cingulate Cortex Microstructural Damage With Postoperative Delirium.

Anesthesia and analgesia·2026

Same author

A Roadmap to Navigate the Future of Neural Engineering.

Journal of neural engineering·2026

Same author

Handgrip strength relates to corticospinal tract microstructure in older adults.

Brain research bulletin·2026

Same author

Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging.

Magma (New York, N.Y.)·2026

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging.

David J Madden¹, Ilana J Bennett, Allen W Song

¹Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA. djm@geri.duke.edu

Neuropsychology Review

|August 26, 2009

Summary

White matter integrity is crucial for cognitive function. Diffusion tensor imaging (DTI) studies reveal that declining white matter integrity in aging adults impacts perceptual speed and executive functions.

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Related Experiment Videos

Last Updated: Jun 20, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

Neuroscience
Cognitive Science
Radiology

Background:

Cerebral white matter integrity is essential for cognitive processing.
The specific role of white matter integrity in age-related cognitive changes remains unclear.

Purpose of the Study:

To review Diffusion Tensor Imaging (DTI) studies on aging.
To understand the implications of white matter integrity for age-related cognitive performance differences.

Main Methods:

Review of Diffusion Tensor Imaging (DTI) studies focusing on aging.
Analysis of DTI measures characterizing white matter properties.

Main Results:

Declining white matter integrity contributes to neural disconnection.
This disconnection consistently affects perceptual speed and executive functioning.
Age-related white matter changes may follow an anterior-posterior gradient across brain regions.

Conclusions:

DTI is a promising tool for understanding cognitive aging.
Findings support theories of cognitive aging and offer translational applications.
Improvements in DTI resolution and integration with functional imaging will enhance future research.