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Related Concept Videos

Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Antidotes01:17

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Behavior Therapy01:22

Behavior Therapy

Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Cognitive Therapy01:25

Cognitive Therapy

Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...

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Updated: Jun 20, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

Anticomplement therapy.

Prathit A Kulkarni1, Vahid Afshar-Kharghan

  • 1Baylor College of Medicine, Houston, Texas, USA;

Biologics : Targets & Therapy
|August 27, 2009
PubMed
Summary
This summary is machine-generated.

The complement system, part of innate immunity, can cause disease when overactive. Anticomplement therapies show promise for treating conditions like paroxysmal nocturnal hemoglobinuria and heart disease.

Keywords:
cardiopulmonary bypasscomplementglomerulonephritismyocardial infarctionparoxysmal nocturnal hemoglobinuria

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Area of Science:

  • Immunology
  • Innate Immunity
  • Complement System

Background:

  • The complement system is crucial for innate immunity but can dysregulate, leading to or exacerbating diseases.
  • Anticomplement reagents have evolved from research tools to viable therapeutic agents.

Purpose of the Study:

  • To review the role of the complement system in various diseases.
  • To discuss the therapeutic potential of anticomplement agents in preclinical and clinical settings.

Main Methods:

  • Literature review of complement system's role in disease.
  • Analysis of anticomplement therapy applications in animal models and human trials.

Main Results:

  • The complement system is implicated in paroxysmal nocturnal hemoglobinuria, glomerulonephritis, and cardiovascular diseases.
  • Anticomplement therapies are being investigated for these conditions.

Conclusions:

  • Targeting the complement system offers a therapeutic strategy for immune-mediated and inflammatory diseases.
  • Further research and clinical trials are essential to establish anticomplement therapies.