Related Experiment Video
Updated: Jun 20, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Cu2+ coordination properties of a 2-pyridine heptaamine tripod: characterization and binding mechanism
Alejandra Sornosa Ten1, Nicolas Humbert, Begoña Verdejo
1Laboratoire de Physico-Chimie Bioinorganique, Institut de Chimie, UMR 7177 CNRS-UdS, Université de Strasbourg, ECPM 25, rue Becquerel, 67200 Strasbourg, France.
Abstract:
The synthesis, protonation, and Cu(2+) coordination chemistry of a tripodal heptaamine ligand (L(1)) functionalized with 2-pyridine fragments at the ends of its three branches are reported. L(1) presents six relatively high protonation constants followed by much more reduced constant that as indicated by the UV-vis and NMR data, occur on the pyridine fragments. p[H]-metric, ESI/MS(+), EPR and UV-vis data show that L(1) is able to form mono-, di-, and trinuclear Cu(2+) complexes. Slippage movements and molecular reorganizations have been observed to occur as a function of p[H] in the 1:1 Cu(2+) complexes. The kinetic studies showed that the complex formation is fast and proceeds through a dissociative Eigen-Wilkins mechanism. The decomposition of CuL(1) upon addition of acid excess occurs with two separate kinetic steps; the rate constant for the fast process does not vary with respect to the H(+) concentration whereas a linear dependence on H(+) is observed for the slow step.
Related Concept Videos
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
Valence Bond Theory
Coordination Number and Geometry
Basicity of Heterocyclic Aromatic Amines
Chair Conformation of Cyclohexane
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...
Conformations of Cyclohexane
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal tetrahedral value,...

