Related Experiment Video

Updated: Jun 20, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
12:29

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus

Published on: April 19, 2017

Mycotic keratitis due to Aspergillus nomius

Palanisamy Manikandan1, János Varga, Sándor Kocsubé

  • 1Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Avinashi Road, Coimbatore 641 014, Tamilnadu, India.

Journal of Clinical Microbiology
|August 28, 2009
PubMed

Insights

This study details the first documented fungal keratitis case caused by Aspergillus nomius, following an ocular injury. Treatment involved antifungal eye drops, ointments, oral medication, and ultimately, a corneal transplant.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Fungal keratitis is a serious eye infection that can lead to vision loss.
  • Aspergillus species are common causes of fungal keratitis, but Aspergillus nomius is rarely reported.
  • Ocular trauma is a significant risk factor for developing fungal keratitis.

Observation:

  • A patient presented with fungal keratitis after a known ocular injury.
  • The causative agent was identified as Aspergillus nomius through sequence-based identification.
  • Clinical presentation included severe corneal inflammation and ulceration.

Findings:

  • Successful treatment involved a combination of topical (natamycin, econazole, itraconazole) and oral (ketoconazole) antifungal agents.
  • Despite medical treatment, therapeutic penetrating keratoplasty was required 16 days post-presentation due to disease progression.
  • This case highlights Aspergillus nomius as a potential pathogen in fungal keratitis.

Implications:

  • This case expands the spectrum of Aspergillus species implicated in human ocular infections.
  • Early diagnosis and appropriate antifungal therapy are crucial for managing fungal keratitis.
  • Further research is needed to understand the pathogenicity and treatment nuances of Aspergillus nomius ocular infections.

More Related Videos

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...