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Updated: Jun 20, 2026
Epithelial Cell Infection Analyses with Shigella
Published on: February 9, 2024
Increasing resistance to nalidixic acid in Shigella subgroups in a comparative study between 2001-2003 and 2004-2006
S Mamishi1, N Mashoori, N Mahboobi
1Infectious Disease Research Centre, Tehran Padiatrics Centre, Tehran University of Medical Sciences, Dr Gharib Avenue, Bagher Khan Street, Tehran, Iran.
Introduction:
The Shigella spp. is an organism with an ongoing changing resistance pattern to different antibiotics, thus making its appropriate treatment difficult. Nalidixic acid has been one of the most common agents used for the treatment of shigellosis. Recently, some studies have reported an emerging resistance to this agent.
Methods:
In this study, we compared the resistance of Shigella isolates during the period 2001-2003 with the period 2004-2006.
Results:
Shigella spp. resistance was increased totally and in each subgroup, except for Shigella sonnei.
Conclusion:
Our results showed an increasing resistance of the Shigella spp., thus identifying an emergent need for an alternative agent for the treatment of shigellosis in future.
Insights
Antibiotic resistance in Shigella spp. is increasing, complicating shigellosis treatment. This study observed rising nalidixic acid resistance in Shigella isolates, highlighting the urgent need for alternative therapies.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Shigella spp. exhibit evolving antibiotic resistance patterns, complicating treatment.
- Nalidixic acid is a common treatment for shigellosis.
- Emerging resistance to nalidixic acid has been reported in Shigella.
Purpose of the Study:
- To compare the antibiotic resistance of Shigella isolates between two distinct time periods.
- To assess the trend of nalidixic acid resistance in Shigella.
Main Methods:
- Comparative analysis of Shigella isolate resistance data.
- Data collection and analysis spanning two periods: 2001-2003 and 2004-2006.
Main Results:
- A significant increase in Shigella spp. resistance was observed overall.
- Resistance increased across most Shigella subgroups.
- Shigella sonnei showed an exception to the increasing resistance trend.
Conclusions:
- The study confirms an escalating resistance in Shigella spp. to common antibiotics.
- An urgent need for novel therapeutic agents for shigellosis is identified.
- Future treatment strategies for shigellosis may require alternatives to current antibiotics.
