Mannose-binding lectin as a risk factor for acute coronary syndromes
Erkki Pesonen1, Mikko Hallman, Seppo Sarna
1Department of Pediatric Cardiology, University Hospital of Lund, Sweden. erkki.pesonen@skane.se
Annals of Medicine
|August 28, 2009
Summary
Elevated microbial infections, like enterovirus, increase the risk of acute coronary events. Mannose-binding lectin (MBL) may play a dual role in immunity and cardiovascular disease risk.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Infectious Disease
Background:
- Mannose-binding lectin (MBL) is a key protein in the innate immune system.
- Its role in acute coronary events, alongside microbial antibodies, was investigated.
Purpose of the Study:
- To determine if MBL and elevated viral/bacterial antibodies are risk factors for acute coronary events.
- To explore the relationship between MBL levels, genotypes, and cardiovascular risk.
Main Methods:
- A controlled cohort study comparing 354 patients with unstable angina pectoris (UA) or acute myocardial infarction (AMI) to 334 controls.
- Analysis included enterovirus and Chlamydia pneumoniae titres, MBL concentrations, and MBL genotypes.
Main Results:
- Enterovirus titres significantly increased UA and AMI risk (OR 10.04, P<0.001; OR 3.18, P=0.003).
- High MBL genotypes were associated with increased UA and AMI risk (OR 1.16, P=0.010; OR 1.12, P=0.007).
- Elevated MBL concentrations in the acute phase correlated with levels after recovery (r=0.85, P<0.001).
Conclusions:
- Elevated microbial titres indicate ongoing inflammation and are linked to cardiovascular events.
- MBL may have a dual role: reducing infection susceptibility while potentially increasing acute coronary syndrome risk.
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