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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Causes of Social Behavior III: Biological and Environmental Influences01:28

Causes of Social Behavior III: Biological and Environmental Influences

Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...

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Related Experiment Video

Updated: Jun 20, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Environmental influences on epigenetic profiles.

Melissa A Suter1, Kjersti M Aagaard-Tillery

  • 1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.

Seminars in Reproductive Medicine
|August 28, 2009
PubMed
Summary

Environmental exposures during pregnancy can alter gene expression and DNA methylation, impacting not only the developing fetus but also future generations. This review highlights key findings in environmental epigenetics.

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Area of Science:

  • Environmental epigenetics
  • Molecular biology
  • Developmental toxicology

Background:

  • Exogenous exposures can influence biological systems.
  • Epigenetic modifications (DNA methylation, histone modifications) are key mediators of gene expression.
  • Environmental factors are increasingly recognized as critical determinants of health outcomes.

Purpose of the Study:

  • To review recent advances in environmental epigenetics.
  • To highlight studies on in utero exposures and their transgenerational effects.
  • To summarize research on maternal behavior, diet, and toxin exposure impacts.

Main Methods:

  • Literature review of seminal studies in environmental epigenetics.
  • Analysis of research linking environmental challenges to epigenetic changes.
  • Synthesis of findings on maternal exposures and offspring epigenomes.

Main Results:

  • Environmental exposures (pollutants, toxins, diet, behavior) induce epigenetic alterations.
  • In utero exposures can modify the epigenome of the fetus.
  • Epigenetic changes can be transmitted to subsequent generations.

Conclusions:

  • Maternal environment plays a crucial role in fetal epigenome development.
  • Environmental epigenetics offers insights into developmental origins of health and disease.
  • Transgenerational epigenetic inheritance is a significant area of research.