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[Quality of interaction database management systems]
A Rodríguez-Terol1, M O Caraballo, D Palma
1Servicio de Suministros Farmacéuticos, Servicio Andaluz de Salud, Sevilla, España.
Summary
Many drug interaction databases (DID) lack essential quality criteria. A third meet minimum standards, highlighting significant structural defects in widely referenced resources.
Area of Science:
- Pharmacology
- Information Science
- Clinical Pharmacy
Background:
- Drug interactions pose a significant risk to patient safety.
- Accurate and comprehensive drug interaction databases (DID) are crucial for healthcare professionals.
- The structural quality of existing DID varies, impacting their utility.
Purpose of the Study:
- To systematically identify available drug interaction databases (DID).
- To critically assess the structural quality and completeness of these DID.
Main Methods:
- Literature search to identify DID.
- Defined exclusion and structural quality criteria (e.g., severity classification, evidence level, references, clinical management).
- Evaluated compliance of identified DID against these defined criteria.
Main Results:
- 54 DID were identified; 30 met exclusion criteria, 15 met minimum criteria.
- Top-performing DID included Bot-plus and Medinteract (100% compliance), followed by SEFH Guide, Lexi-interact, and Medscape (89%).
- Commonly included features were mechanism of action (92%) and classification by active ingredient (87%), while electronic format and ease of search were noted in 75%.
Conclusions:
- Only one-third of evaluated DID meet minimum quality standards.
- Significant structural defects exist in prominent DID, including lack of web presentation and multi-check functionality.
- Discrepancies in quality and compliance were observed between Spanish and international DID.
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