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[Quality of interaction database management systems].

A Rodríguez-Terol¹, M O Caraballo, D Palma

¹Servicio de Suministros Farmacéuticos, Servicio Andaluz de Salud, Sevilla, España.

Farmacia Hospitalaria : Organo Oficial De Expresion Cientifica De La Sociedad Espanola De Farmacia Hospitalaria

|August 29, 2009

Summary

This summary is machine-generated.

Many drug interaction databases (DID) lack essential quality criteria. A third meet minimum standards, highlighting significant structural defects in widely referenced resources.

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Area of Science:

Pharmacology
Information Science
Clinical Pharmacy

Background:

Drug interactions pose a significant risk to patient safety.
Accurate and comprehensive drug interaction databases (DID) are crucial for healthcare professionals.
The structural quality of existing DID varies, impacting their utility.

Purpose of the Study:

To systematically identify available drug interaction databases (DID).
To critically assess the structural quality and completeness of these DID.

Main Methods:

Literature search to identify DID.
Defined exclusion and structural quality criteria (e.g., severity classification, evidence level, references, clinical management).
Evaluated compliance of identified DID against these defined criteria.

Main Results:

54 DID were identified; 30 met exclusion criteria, 15 met minimum criteria.
Top-performing DID included Bot-plus and Medinteract (100% compliance), followed by SEFH Guide, Lexi-interact, and Medscape (89%).
Commonly included features were mechanism of action (92%) and classification by active ingredient (87%), while electronic format and ease of search were noted in 75%.

Conclusions:

Only one-third of evaluated DID meet minimum quality standards.
Significant structural defects exist in prominent DID, including lack of web presentation and multi-check functionality.
Discrepancies in quality and compliance were observed between Spanish and international DID.