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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Angiotensin II type 1 receptor gene polymorphism in myocardial infarction patients
Bhoomi Reddy Pullareddy1, Baddela Muni Venkata Srikanth Babu, Kolla Venkata Karunakar
1Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad 500016, India.
Introduction:
Acute myocardial infarction is commonly known as heart attack. It is a multifactorial disease influenced by environmental and genetic factors.The objective of the present study was to investigate the association of the angiotensin II type 1 receptor gene A/C polymorphism in South Indian myocardial infarction patients.Subjects and methods. The present study included a total number of 221 subjects (107 myocardial infarction patients and 114 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the angiotensin II type 1 receptor gene A/C polymorphism was determined by polymerase chain reaction.
Results:
Comparison of the lipid profiles between patients and controls showed that patients had statistically highly significant values (p=0.0001).The CC genotype of the angiotensin II type 1 receptor was not associated with myocardial infarction patients when compared to controls. CC vs. AA was chi(2) = 2.08, odds ratio 2.30, 95% confidence interval 0.72 - 7.23, and p value was 0.14.
Conclusion:
The angiotensin II type 1 receptor CC genotype is not a risk factor for myocardial infarction in patients in a South Indian population.
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