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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Genome-wide Association Studies-GWAS01:11

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Related Experiment Video

Updated: Jun 20, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Polymyalgia rheumatica prevalence in a population-based sample.

S Bernatsky1, L Joseph, C A Pineau

  • 1McGill University Health Centre, Montreal, Quebec, Canada. sasha.bernatsky@mail.mcgill.ca

Arthritis and Rheumatism
|August 29, 2009
PubMed
Summary
This summary is machine-generated.

Polymyalgia rheumatica (PMR) prevalence is higher in rural areas compared to urban areas. This study highlights the importance of using advanced statistical methods to accurately estimate disease prevalence from administrative data.

Related Experiment Videos

Last Updated: Jun 20, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Epidemiology
  • Rheumatology
  • Health Services Research

Background:

  • Polymyalgia rheumatica (PMR) is a common inflammatory condition affecting individuals over 45 years old.
  • Accurate prevalence data are crucial for resource allocation and understanding disease burden.
  • Administrative databases offer a potential source for prevalence estimation, but case ascertainment challenges exist.

Purpose of the Study:

  • To determine the prevalence of polymyalgia rheumatica (PMR) using population-based administrative data.
  • To estimate the accuracy and error associated with different case ascertainment methods in these databases.
  • To assess demographic and regional variations in PMR prevalence.

Main Methods:

  • Utilized physician billing and hospitalization data from Manitoba, Canada (population 1.1 million).
  • Compared three case definition algorithms for PMR in individuals aged 45 years and older.
  • Employed a hierarchical Bayesian latent class regression model to account for imperfect case ascertainment and analyze demographic differences.

Main Results:

  • Estimated PMR prevalence was higher in rural areas (1,004/100,000 women, 380.7/100,000 men) compared to urban areas (754.5/100,000 women, 273.6/100,000 men).
  • Physician billing data demonstrated higher sensitivity for case ascertainment than hospitalization data.
  • A significant proportion of PMR diagnoses were made by non-rheumatologists.

Conclusions:

  • Suggests a higher prevalence of PMR in rural populations compared to urban populations.
  • Demonstrates the utility of statistical methods that adjust for imperfect data sources.
  • Provides a framework for estimating the sensitivity of various case ascertainment approaches in administrative health data.