Related Experiment Video
Updated: Jun 20, 2026
08:07
Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification
Published on: August 1, 2025
Secondary hyperparathyroidism after kidney transplantation: a cross-sectional study
R Marcén1, B Ponte, N Rodríguez-Mendiola
1Department of Nephrology, Hospital Ramón y Cajal, Madrid, Spain. rmarcen.hrc@salud.madrid.org
Transplantation Proceedings
|September 1, 2009
Summary
Most kidney transplant recipients have high intact parathyroid hormone (iPTH) levels, indicating persistent hyperparathyroidism. Treatment with vitamin D showed a modest improvement in iPTH levels in these patients.
Area of Science:
- Nephrology
- Endocrinology
- Biochemistry
Background:
- Hyperparathyroidism is a common complication in kidney transplant recipients.
- Understanding its prevalence and associated factors is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of hyperparathyroidism in kidney graft recipients.
- To identify factors associated with persistent high parathyroid hormone levels.
Main Methods:
- Biochemical bone parameters were analyzed in 509 renal transplant recipients.
- Patients' treatment with vitamin D or calcium supplements was recorded.
- Intact parathyroid hormone (iPTH) and estimated glomerular filtration rate (eGFR) were measured.
Main Results:
- Approximately 80% of patients exhibited elevated iPTH levels.
- Hypercalcemia was present in 13.7% of the cohort.
- Lower eGFR, longer dialysis time, and reduced 25-hydroxyvitamin D (25OHD) predicted higher iPTH.
Conclusions:
- Persistent hyperparathyroidism is highly prevalent post-kidney transplantation.
- Graft dysfunction, prolonged dialysis, and low 25OHD are linked to hyperparathyroidism.
- Vitamin D supplementation offered a marginal benefit in reducing hyperparathyroidism prevalence.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
00:59The Parathyroid Glands
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
01:25Chronic Kidney Disease I: Introduction
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...