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The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease

O Gojis1, B Rudraraju, C Alifrangis

  • 1Department of Gynaecology and Obstetrics, Third Faculty of Medicine, Charles University, Ruska 87, Prague 10, 100 00, Czech Republic.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|September 1, 2009
PubMed
Abstract

Insights

Steroid receptor coactivator-3 (SRC-3) is overexpressed in many cancers and may serve as a prognostic marker for aggressive disease, particularly in prostate and ovarian cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The p160 steroid receptor coactivator (SRC) family, including SRC-3, plays a crucial role in nuclear hormone receptor transcriptional activity.
  • SRC-3 amplification and expression are observed in breast cancer and other malignant diseases.
  • Understanding SRC-3's role in carcinogenesis may yield new prognostic markers and therapeutic targets.

Purpose of the Study:

  • To review the literature on SRC-3 expression in human malignant diseases outside the breast.
  • To assess the potential prognostic and predictive value of SRC-3 in various cancers.
  • To identify potential therapeutic implications of SRC-3 in oncology.

Main Methods:

  • A comprehensive literature search of PubMed and MEDLINE databases was conducted up to February 28, 2009.
  • English-language articles were included, using search terms "SRC-3", "AIB1", "human", "cancer", and "malignant disease".
  • The focus was on malignant diseases originating outside the breast, with full article retrieval and reference checking.

Main Results:

  • SRC-3 is amplified and expressed across a broad spectrum of human cancers.
  • SRC-3 expression shows potential as a prognostic marker in diverse tumor types.
  • Evidence suggests SRC-3 involvement in the risk of developing prostate and ovarian cancers.

Conclusions:

  • SRC-3 is implicated in the pathogenesis of prostate and ovarian cancers.
  • SRC-3 presence correlates with aggressive disease characteristics.
  • Further research is needed to fully establish SRC-3's predictive and prognostic utility due to limited studies per cancer type.

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