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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 20, 2026

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

Published on: February 14, 2019

Sweet tasting chips: microarray-based analysis of glycans.

Ku-Lung Hsu¹, Lara K Mahal

¹Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, Austin, TX 78712-0265, USA.

Current Opinion in Chemical Biology

|September 1, 2009

Summary

This summary is machine-generated.

Glycomics, the study of glycans, is advancing with new lectin-based microarray tools. These technologies aid in discovering disease biomarkers and understanding biological processes like HIV-1 exit.

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Area of Science:

Biochemistry
Molecular Biology
Analytical Chemistry

Background:

Glycosylation is a crucial post-translational modification, creating diverse protein and lipid functions.
Glycomics, the systematic study of glycans, is a rapidly growing field in the postgenomic era.
Carbohydrate analysis presents inherent complexities, necessitating advanced analytical tools.

Purpose of the Study:

To highlight novel lectin-based microarray technologies.
To underscore the role of these technologies in the emerging field of glycomics.
To demonstrate the utility of glycomics tools in clinical and research applications.

Main Methods:

Development of advanced analytical tools for glycan analysis.
Utilization of lectin-based microarray technologies.
Application of these technologies in clinical and research settings.

Main Results:

Lectin-based microarrays offer powerful capabilities for glycan analysis.
These tools have been successfully applied to identify novel disease biomarkers.
The technologies are instrumental in studying complex biological mechanisms, such as HIV-1 exit.

Conclusions:

Lectin-based microarray technologies are essential for advancing glycomics.
These tools facilitate the identification of disease biomarkers and enhance understanding of biological processes.
Glycomics, empowered by these technologies, holds significant promise for both clinical and research advancements.