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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

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Related Experiment Video

Updated: Jun 20, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Granulomatous disease in common variable immunodeficiency.

Omür Ardeniz1, Charlotte Cunningham-Rundles

  • 1Ege University Medical Faculty, Department of Internal Medicine, Division of Allergy and Clinical Immunology, Izmir, Turkey.

Clinical Immunology (Orlando, Fla.)
|September 1, 2009
PubMed
Summary
This summary is machine-generated.

Granulomatous disease affects over 8% of common variable immunodeficiency (CVID) patients. This study details the clinical features, autoimmune links, and outcomes for CVID patients with granulomas, finding similar mortality to those without granulomas.

Related Experiment Videos

Last Updated: Jun 20, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Area of Science:

  • Immunology
  • Clinical Medicine
  • Rheumatology

Background:

  • Granulomatous disease is a known complication in patients with common variable immunodeficiency (CVID).
  • The prevalence of granulomas in CVID patients ranges from 8-22%.
  • Understanding the clinical spectrum and outcomes of granulomatous disease in CVID is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical and immunological characteristics of CVID patients diagnosed with granulomatous disease.
  • To analyze the timing of granuloma diagnosis relative to CVID diagnosis.
  • To assess the impact of granulomas on patient outcomes, including mortality.

Main Methods:

  • Retrospective analysis of clinical and immunological data from 37 CVID patients with granulomas.
  • Review of medical records for diagnosis dates, affected organs, co-existing autoimmune diseases, treatments, and survival.
  • Comparison of mortality rates between CVID patients with and without granulomas.

Main Results:

  • Granulomas were diagnosed before, during, or after CVID diagnosis in 37 patients (8.1% of 455 CVID subjects).
  • Common sites for granulomas included lungs (54%), lymph nodes (43%), and liver (32%).
  • Over half (54%) had autoimmune diseases, and 51.3% required steroid treatment for granulomas; mortality was not significantly higher than in CVID patients without granulomas.

Conclusions:

  • Granulomatous disease in CVID presents with diverse clinical manifestations and is associated with a high rate of autoimmune comorbidities.
  • While granulomas require significant medical intervention, they do not appear to substantially increase long-term mortality in CVID patients.
  • Further research into the pathogenesis and optimal management of granulomatous disease in CVID is warranted.