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Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

Assessment of autonomic dysfunction and anxiety levels in patients with mitral valve prolapse

Ahmet L Orhan1, Nurten Sayar, Zekeriya Nurkalem

  • 1Department of Cardiology, Siyami Ersek Cardiovascular Surgery Center, Istanbul, Turkey. lutfu.orhan@yahoo.com

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|September 1, 2009
PubMed
Abstract

Insights

Patients with mitral valve prolapse (MVP) syndrome exhibit greater anxiety and autonomic dysfunction than those with anatomical MVP. This highlights distinct clinical profiles within MVP, emphasizing the need for tailored management strategies.

Area of Science:

  • Cardiology
  • Autonomic Nervous System Research
  • Psychosomatic Medicine

Background:

  • Mitral valve prolapse (MVP) is a common cardiac condition with varying clinical presentations.
  • Autonomic dysfunction and anxiety are frequently reported in patients with MVP, but their relationship with specific MVP subtypes is not fully elucidated.

Purpose of the Study:

  • To investigate and compare autonomic dysfunction parameters and anxiety levels between patients with anatomical MVP and MVP syndrome.
  • To explore the correlation between autonomic dysfunction and anxiety in patients with MVP.

Main Methods:

  • A cohort of 33 patients with MVP and 14 healthy controls were evaluated.
  • Patients were classified into anatomical MVP (n=11) or MVP syndrome (n=22) based on leaflet thickening.
  • Anxiety was assessed using Spielberger's Situational Anxiety Scale (SSAS) and Continuous Anxiety Scale (SCAS). Autonomic function was evaluated via heart rate (HR) and arterial blood pressure (BP) measurements in supine and standing positions.

Main Results:

  • MVP syndrome patients reported significantly higher SSAS and SCAS scores compared to anatomical MVP patients and controls (p<0.001).
  • Greater orthostatic differences in BP and HR were observed in MVP syndrome patients (p<0.001 and p=0.032, respectively).
  • Orthostatic HR differences correlated significantly with anxiety scores (SSAS and SCAS), and orthostatic BP differences showed an inverse correlation with anxiety parameters in all MVP patients.

Conclusions:

  • Patients with MVP syndrome demonstrate significantly increased autonomic dysfunction and anxiety levels compared to those with anatomical MVP.
  • These findings suggest distinct pathophysiological mechanisms and clinical manifestations between MVP subtypes.
  • Further research is warranted to understand the implications for patient management and therapeutic interventions.

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