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Related Experiment Video

Updated: Jun 20, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

IL-21 is critical for GVHD in a mouse model.

A Meguro1, K Ozaki, I Oh

  • 1Division of Hematology, Department of Medicine, Jichi Medical University Tochigi, Tochigi, Japan.

Bone Marrow Transplantation
|September 1, 2009
PubMed
Summary

Interleukin-21 (IL-21) blockade significantly reduces graft-versus-host disease (GVHD) severity and mortality in mice. Blocking IL-21 signaling offers a potential new strategy for preventing GVHD after bone marrow transplantation (BMT).

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Related Experiment Videos

Last Updated: Jun 20, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
06:06

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

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Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice
09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

Area of Science:

  • Immunology
  • Transplantation immunology
  • Cellular immunology

Background:

  • Interleukin-21 (IL-21) is known to affect T, B, and natural killer (NK) cells.
  • The specific role of IL-21 in graft-versus-host disease (GVHD) is not well understood.

Purpose of the Study:

  • To investigate the role of IL-21 in the pathogenesis of GVHD.
  • To explore the potential of blocking IL-21 signaling as a strategy for GVHD prophylaxis.

Main Methods:

  • Bone marrow transplantation (BMT) was performed using splenocytes from IL-21 receptor knockout (IL-21R(-/-)) mice and wild-type mice.
  • A decoy receptor for IL-21 was generated and used to transduce bone marrow (BM) cells for BMT.

Main Results:

  • Morbidity and mortality associated with GVHD were significantly reduced when using splenocytes from IL-21R(-/-) mice compared to wild-type mice.
  • Mice receiving BM cells transduced with the IL-21 decoy receptor exhibited less severe GVHD compared to control groups.

Conclusions:

  • IL-21 plays a critical role in regulating GVHD.
  • Blocking the IL-21 signaling pathway presents a promising novel strategy for the prophylaxis of GVHD.