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Updated: Jun 20, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[A woman with muscle weakness and skin rash]
1Revmatologisk avdeling, Oslo universitetssykehus, Rikshospitalet, 0027 Oslo, Norway. jan.tore.gran@rikshospitalet.no
Abstract:
A 44-year-old woman complained about weak proximal muscles in arms and legs. Levels of muscle enzymes in serum and findings in muscle biopsies were both normal. She then developed slight dyspnoea on exertion and high resolution CT showed ground glass opacities. Later on, dermatological manifestations such as V-sign and Shawl-sign were observed and the patient complained of Raynaud's phenomenon. Capillaroscopy revealed slight dearrangement of capillary architecture and reduced capillary density. The diagnosis was hypomyopathic dermatomyositis. Clinical aspects of amyopathic and hypomyopathic dermatomyositis are discussed.
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