Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medical Student Wellbeing Requires Purpose, Not Just Protection.

American journal of lifestyle medicine·2026
Same author

Safety Assessment of <i>Melaleuca alternifolia</i> (Tea Tree)-Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026
Same author

Safety Assessment of Radish Root - Derived Ingredients as Used in Cosmetics.

International journal of toxicology·2026
Same author

Amended Safety Assessment of Naturally-Sourced Clays as Used in Cosmetics.

International journal of toxicology·2026
Same author

Safety Assessment of Diatomaceous Earth as Used in Cosmetics.

International journal of toxicology·2026
Same author

Safety Assessment of Basic Yellow 87 as Used in Cosmetics.

International journal of toxicology·2026

Related Experiment Video

Updated: Jun 20, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Grover disease (transient acantholytic dermatosis).

Joshua Weaver1, Wilma F Bergfeld

  • 1Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA. weaverj3@ccf.org

Archives of Pathology & Laboratory Medicine
|September 3, 2009
PubMed
Summary

Grover disease, or transient acantholytic dermatosis, is a common but temporary skin rash. Its exact cause is unknown, but it may be linked to other health issues, requiring careful biopsy examination.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Grover disease (transient acantholytic dermatosis) presents as a pruritic, papulovesicular rash on the upper trunk.
  • It typically affects older white males and is characterized by spontaneous remission, complicating evaluation.

Purpose of the Study:

  • To discuss diagnostic considerations for Grover disease.
  • To explore its postulated pathogenesis, associated disorders, and the pathologist's role in diagnosis.

Main Methods:

  • Review of diagnostic criteria for Grover disease.
  • Analysis of histological patterns and associated conditions from skin biopsies.

Main Results:

  • Grover disease exhibits four distinct acantholytic histologic patterns.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Related Experiment Videos

Last Updated: Jun 20, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

  • It is frequently associated with other dermatologic and nondermatologic conditions, including hematologic malignancies.

    • Conclusions:

    • The pathogenesis of Grover disease remains largely unknown.
    • Thorough examination of skin biopsies is crucial to rule out concomitant disorders, particularly hematopoietic malignancies.