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Cyclooxygenase-2 expression in cervical intraepithelial neoplasia
Kidong Kim1, Yong-Tark Jeon, In-Ae Park
1Department of Obstetrics and Gynecology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Annals of the New York Academy of Sciences
|September 3, 2009
Summary
Cyclooxygenase (COX)-2 is expressed in the dysplastic epithelium of cervical intraepithelial neoplasia (CIN), not stromal cells. This COX-2 expression in CIN epithelium correlates with patient age and menopausal status.
Area of Science:
- Oncology
- Cell Biology
- Immunohistochemistry
Background:
- Cervical carcinogenesis involves cellular changes in the cervix.
- Cyclooxygenase (COX)-2 is implicated in various cancers.
- The role of COX-2 in cervical intraepithelial neoplasia (CIN) requires further elucidation.
Purpose of the Study:
- To investigate the expression patterns of cyclooxygenase (COX)-2 in cervical intraepithelial neoplasia (CIN).
- To determine the localization of COX-2 expression within CIN tissues (epithelium vs. stroma).
- To examine the correlation between COX-2 expression and clinicopathological variables in CIN patients.
Main Methods:
- Immunohistochemical analysis using COX-2 antibody.
- Examination of 148 paraffin-embedded CIN tissue specimens.
- Separate evaluation of COX-2 expression in dysplastic epithelium and stromal cells.
Main Results:
- COX-2 expression was detected in the dysplastic epithelium of 7.4% of CIN specimens.
- COX-2 expression was absent in all stromal cells of CIN specimens.
- Epithelial COX-2 expression was significantly higher in older and postmenopausal women.
Conclusions:
- Cyclooxygenase (COX)-2 is expressed in the dysplastic epithelium, but not stromal cells, of cervical intraepithelial neoplasia (CIN).
- The presence of COX-2 in CIN epithelium is associated with patient age and menopausal status.
- These findings suggest a potential role for COX-2 in specific cellular compartments during cervical carcinogenesis.
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