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Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease
D P Geaney1, N Soper, B J Shepstone
1University of Oxford, Department of Psychiatry, Warneford Hospital, UK.
Lancet (London, England)
|June 23, 1990
Abstract:
Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.