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Updated: Jun 20, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Clozapine-induced bowel infarction: a case report.

Nicholas D McKinnon¹, Alvi Azad, Brian M Waters

¹US Air Force (Wilford Hall Medical Center, Lackland AFB, Texas) and the University of Texas Health Science Center at San Antonio, Texas, USA. nicholas.mckinnon@lackland.af.mil

Psychiatry (Edgmont (Pa. : Township))

|September 3, 2009

Summary

Clozapine effectively treats resistant schizophrenia but carries risks. This case highlights severe gastrointestinal issues, including bowel infarctions, necessitating surgery despite clozapine

Keywords:

atypical antipsychotic bowel surgery clozapine constipation ischemic colitis schizoaffective disorder

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Last Updated: Jun 20, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

Psychiatry and Pharmacology

Background:

Resistant schizophrenia often requires clozapine when standard antipsychotics fail or cause side effects.
Clozapine is a secondary treatment option due to serious potential side effects like agranulocytosis, requiring constant blood monitoring.

Observation:

A 40-year-old female patient experienced chronic constipation and bowel infarctions.
These severe gastrointestinal complications arose after long-term clozapine treatment.

Findings:

The patient underwent multiple abdominal surgeries, including subtotal colonic resections, due to clozapine-induced complications.
Despite the severe side effects and surgical interventions, clozapine remained the only effective treatment for her schizophrenic symptoms after other medications failed.

Implications:

This case underscores the critical balance between clozapine's efficacy in treatment-resistant schizophrenia and its significant gastrointestinal risks.
Highlights the need for vigilant monitoring of gastrointestinal health in patients on long-term clozapine therapy.
Emphasizes the challenges in managing patients who require clozapine despite its adverse effects.