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Imparting multivalency to a bifunctional chelator: a scaffold design for targeted PET imaging probes

Wei Liu1, Guiyang Hao, Michael A Long

  • 1Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8542, USA.

Angewandte Chemie (International Ed. in English)
|September 3, 2009
PubMed
Abstract

No abstract available in PubMed .

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Complexation Equilibria: The Chelate Effect01:19

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In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...

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