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Basilar artery steno-occlusive disease is associated with structural changes in the left ventricle

Kyusik Kang1, Seung-Hoon Lee, Byung-Woo Yoon

  • 1Department of Neurology, Gyeongsang National University Hospital, Jinju, Republic of Korea.

Acta Cardiologica
|September 4, 2009
PubMed

Insights

Increased left ventricular (LV) relative wall thickness is linked to basilar artery steno-occlusive disease in stroke patients. This finding suggests LV wall thickness may be a risk factor or share causes with basilar artery disease.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Medicine

Background:

  • Extracranial carotid artery structural changes correlate with increased left ventricular (LV) mass and relative wall thickness.
  • Understanding intracranial artery disease in stroke patients is crucial for risk stratification.

Purpose of the Study:

  • To investigate the relationship between LV mass index, relative wall thickness, and intracranial atherosclerotic steno-occlusive disease.
  • To assess these cardiac parameters in noncardioembolic ischemic stroke patients using magnetic resonance angiography (MRA).

Main Methods:

  • Retrospective analysis of 212 acute ischemic stroke patients who underwent echocardiography and intracranial MRA.
  • Exclusion of patients with cardioembolic sources or other known vascular steno-occlusive diseases.
  • Classification of patients into four groups based on LV mass index and relative wall thickness (concentric/eccentric hypertrophy, concentric remodeling, normal geometry).

Main Results:

  • Basilar artery (BA) steno-occlusive disease was associated with LV relative wall thickness, but not LV mass index.
  • Prevalence of BA disease was significantly higher in patients with concentric LV hypertrophy compared to normal geometry.
  • Middle cerebral artery steno-occlusive disease showed no strong relation to LV structural changes.

Conclusions:

  • Elevated LV relative wall thickness may serve as an independent risk factor for basilar artery steno-occlusive disease.
  • Shared pathogenic mechanisms might exist between increased LV relative wall thickness and basilar artery disease.
Abstract

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