Related Experiment Video
Updated: Jun 20, 2026
Fluorescence Molecular Tomography for In Vivo Imaging of Glioblastoma Xenografts
Published on: April 26, 2018
Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake
George A Alexiou1, Spyridon Tsiouris, George Vartholomatos
1Department of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece. alexiougrg@yahoo.gr
Objectives:
Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors.
Material And Methods:
In a 10-patient prospective pilot study we evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. (99m)Tc-TF brain SPECT was performed shortly before surgical tumor excision.
Results:
Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between (99m)Tc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001).
Conclusion:
Initial evidence suggests that (99m)Tc-TF could provide a non-invasive indicator of glioma proliferative activity.
