Organizing bioactive compound discovery in target families

Area of Science:

• Biochemistry
• Genomics
• Systems Biology

Background:

• Genome sequencing provides the complete set of an organism's genetic building blocks.
• Various omics technologies investigate the dynamic interactions of these building blocks.
• Understanding organism function relies on analyzing these complex molecular interactions.

Purpose of the Study:

• To discuss how target families facilitate the investigation of biochemical functions.
• To explore the modulation of biochemical functions using target families.
• To demonstrate the application of target families in charting Chemical and Biological Spaces.

Main Methods:

• Clustering of proteins into target families.
• Utilizing phylogenetic and structural similarities for clustering.
• Leveraging omics technologies for data generation.

Main Results:

• Target families provide a framework for organizing and analyzing protein functions.
• Phylogenetic and structural data are key to defining functional protein groups.
• This clustering enables a systematic approach to biochemical research.

Conclusions:

• The concept of target families is crucial for understanding complex biological systems.
• Target families offer a powerful strategy for modulating biochemical processes.
• This approach is essential for exploring and mapping Chemical and Biological Spaces.