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Intradermal antigen tests in psoriasis.

J P McFadden1, A V Powles, B S Baker

  • 1Department of Dermatology, St. Mary's Hospital, London, England.

Acta Dermato-Venereologica
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Delayed hypersensitivity reactions, induced by intradermal antigens, do not effectively trigger the Koebner phenomenon in psoriasis patients. Psoriasis patients exhibit impaired ability to resolve cell-mediated immune responses.

Area of Science:

  • Immunology
  • Dermatology
  • Psoriasis Research

Background:

  • The Koebner phenomenon, characterized by lesion development at sites of injury in psoriasis, is a key aspect of the disease.
  • The role of delayed hypersensitivity in eliciting the Koebner reaction remains incompletely understood.

Purpose of the Study:

  • To investigate whether eliciting delayed hypersensitivity is superior to simple trauma in inducing the Koebner reaction in psoriasis.
  • To assess immune response differences in psoriasis patients compared to controls.

Main Methods:

  • A double-blind study involving 12 psoriasis patients and 9 controls.
  • Intradermal injections of streptokinase/streptodornase, purified protein derivative (PPD), and saline were administered.
  • Evaluation of injected sites for psoriasis development, erythema, and induration over 28 days.

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Main Results:

  • Only one Koebner-positive patient developed psoriasis at injection sites.
  • Koebner-negative psoriatic subjects showed delayed resolution of delayed hypersensitivity reactions to PPD and streptokinase/streptodornase compared to controls.
  • Intradermal antigen injection was not more effective than injury alone in inducing the Koebner phenomenon.

Conclusions:

  • Intradermal antigen challenge, as employed in this study, does not reliably induce the Koebner phenomenon in psoriasis.
  • Psoriasis patients demonstrate a potential impairment in resolving cell-mediated immune reactions.