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Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
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Building limb morphology through integration of signalling modules.

Veronique Duboc1, Malcolm Po Logan

  • 1Division of Developmental Biology, MRC-National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK. vduboc@nimr.mrc.ac.uk

Current Opinion in Genetics & Development
|September 5, 2009
PubMed
Summary

Vertebrate limb development involves signalling centres like the Apical Ectodermal Ridge (AER) and Zone of Polarising Activity (ZPA). Recent research reveals crucial cross-talk between these centres and mesenchymal cells, explaining limb diversity.

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