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Updated: Jun 20, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

CKD associates with cognitive decline.

Minesh Khatri1, Thomas Nickolas, Yeseon P Moon

  • 1Department of Internal Medicine, University of Washington, Seattle, Washington, USA.

Journal of the American Society of Nephrology : JASN
|September 5, 2009
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease (CKD) is linked to cognitive decline in aging adults. This study found that reduced kidney function, even mild CKD, is associated with worse cognitive performance over time.

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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

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Last Updated: Jun 20, 2026

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Area of Science:

  • Gerontology
  • Nephrology
  • Neuroscience

Background:

  • Cognitive impairment and chronic kidney disease (CKD) are growing public health concerns in aging populations.
  • Existing research suggests a link between CKD and cognitive decline, but longitudinal data, especially in diverse groups, is scarce.

Purpose of the Study:

  • To investigate the longitudinal association between chronic kidney disease (CKD) and cognitive function decline.
  • To examine this relationship in a diverse, population-based cohort, addressing limitations in prior studies.

Main Methods:

  • Utilized data from the Northern Manhattan Study, a prospective cohort of stroke-free individuals.
  • Assessed cognitive function annually via the modified Telephone Interview for Cognitive Status (TICS-m).
  • Estimated kidney function using Cockcroft-Gault creatinine clearance (CCl), eGFR, and serum creatinine (sCr), adjusting for sociodemographic and vascular factors.

Main Results:

  • A cohort of 2172 subjects (mean age 71.5 years, 2.9-year follow-up) with significant ethnic diversity (59% Hispanic, 20% Black) was analyzed.
  • Participants with lower kidney function (CCl < 90 ml/min) demonstrated significantly worse cognitive performance over time compared to those with higher function (CCl > 90 ml/min).
  • These findings remained consistent across different measures of kidney function (CCl, eGFR, sCr).

Conclusions:

  • Reduced kidney function is significantly associated with accelerated cognitive decline, even in cases of mild CKD.
  • Kidney disease may represent an important, potentially modifiable mechanism contributing to cognitive impairment in older adults.
  • These findings highlight kidney health as a potential target for interventions aimed at preventing cognitive decline.