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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Stimulant medication use and response to growth hormone therapy: an NCGS database analysis

J Paul Frindik1, Alba Morales, John Fowlkes

  • 1University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. frindikpaul@uams.edu

Hormone Research
|September 5, 2009
PubMed

Insights

The use of ADHD medications in children treated with growth hormone (GH) has increased. Growth responses in the first year of GH therapy were similar for children taking ADHD medication versus those not on medication.

Area of Science:

  • Pediatric Endocrinology
  • Child Psychology

Background:

  • Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
  • Growth hormone (GH) therapy is used to treat various growth disorders in children.

Purpose of the Study:

  • To determine the frequency of ADHD treatment in children receiving GH therapy.
  • To compare growth responses in children on GH with ADHD medication versus GH alone.

Main Methods:

  • Retrospective analysis of pre-pubertal children with idiopathic short stature (ISS) or GH deficiency (IGHD).
  • ADHD treatment was identified by stimulant medication use at enrollment.
  • Growth data from Genentech's National Cooperative Growth Study (1985-2005).

Main Results:

  • ADHD medication use rose from 0.8% in 1985 to 5.8% in 2005.
  • First-year GH response was similar between ADHD + IGHD and IGHD groups (adjusted difference -0.4 cm/year).
  • First-year GH response was similar between ADHD + ISS and ISS groups (adjusted difference -0.2 cm/year).

Conclusions:

  • A growing proportion of children on GH therapy are also treated for ADHD.
  • ADHD medication does not significantly alter first-year growth response to GH therapy in children with ISS or IGHD.
Abstract

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