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Longevity nutrients resveratrol, wines and grapes
Istvan Lekli1, Diptarka Ray, Dipak K Das
1Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110 USA.
Genes & Nutrition
|September 5, 2009
Summary
Moderate wine consumption may reduce vascular and cancer risks, potentially via resveratrol activating longevity genes like SirT1. This review explores resveratrol, wine, and grapes in promoting longevity.
Area of Science:
- Nutritional Science
- Molecular Biology
- Gerontology
Background:
- Moderate wine intake is associated with reduced cardiovascular, cerebrovascular, and peripheral vascular disease risks.
- The cardioprotective effects of wine are often attributed to resveratrol, a key compound found in wine.
- The 'French Paradox' describes the observation of lower rates of heart disease in wine-drinking populations.
Purpose of the Study:
- To review the functional and molecular aspects of resveratrol, wine, and grapes.
- To explore their role in potentiating longevity genes.
- To understand the scientific basis behind the 'French Paradox' and wine's health benefits.
Main Methods:
- Literature review of existing scientific reports and studies.
- Analysis of research on resveratrol's biological functions.
- Examination of molecular pathways involving longevity genes like SirT1.
Main Results:
- Resveratrol activates the longevity gene SirT1, similar to calorie restriction.
- SirT1 activation is linked to extended lifespan in model organisms like yeast.
- Resveratrol, found in wine and grapes, plays a significant role in these observed health benefits.
Conclusions:
- Resveratrol is a key bioactive compound in wine and grapes with significant health implications.
- Activation of longevity genes like SirT1 by resveratrol offers a molecular mechanism for health benefits.
- Further research into resveratrol and its sources may provide insights into promoting longevity and preventing age-related diseases.
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