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Microscopic colitis in children.

Wael El-Matary1, Safwat Girgis, Hien Huynh

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stollery Children's Hospital, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada. WaelElMatary@Capitalhealth.ca

Digestive Diseases and Sciences
|September 5, 2009
PubMed
Summary
This summary is machine-generated.

Microscopic colitis is rare in children, often presenting with watery diarrhea. Most pediatric cases, including lymphocytic and eosinophilic variants, respond well to aminosalicylic acid (5-ASA) treatment.

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Area of Science:

  • Pediatric Gastroenterology
  • Histopathology
  • Inflammatory Bowel Disease

Background:

  • Microscopic colitis typically affects the elderly, presenting with chronic watery diarrhea and normal endoscopic findings.
  • Histopathological examination reveals inflammatory changes, distinguishing it from other diarrheal conditions.
  • Data on pediatric microscopic colitis is limited, necessitating further research.

Purpose of the Study:

  • To characterize the clinical presentation and outcomes of microscopic colitis in children.
  • To identify subtypes and potential contributing factors in pediatric cases.
  • To evaluate treatment responses in this pediatric population.

Main Methods:

  • Retrospective review of pathology and pediatric inflammatory bowel disease databases (1996-2008).
  • Inclusion criteria: children under 17 years with diagnosed microscopic colitis.
  • Analysis of patient charts, including diagnostic findings and treatment outcomes.

Main Results:

  • Eleven children (mean age 11.2 years) were identified with microscopic colitis.
  • Common subtypes included lymphocytic and nonspecific/eosinophilic microscopic colitis.
  • The majority of patients responded well to mesalazine (5-ASA); immunodeficiency cases were challenging.

Conclusions:

  • Microscopic colitis is a rare but distinct condition in the pediatric population.
  • Microscopic eosinophilic colitis is an underrecognized variant.
  • Aminosalicylic acid (5-ASA) is effective for most pediatric cases; immunodeficiency-associated cases require specialized management.
  • Further multicenter pediatric trials are essential for a comprehensive understanding.