Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 20, 2026

Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

Disposable plastic microreactors for genomic analyses.

S Sabella1, G Vecchio, P P Pompa

  • 1National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Via Arnesano 16, 73100 Lecce, Italy. stefania.sabella@unile.it

Biomedical Microdevices
|September 5, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the <sup>235</sup>U fission cross section relative to the standard <sup>10</sup>B(n, α) reaction at the CERN n_TOF facility: Results for E<sub>n</sub>< 2 eV.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025
Same author

Habitat drivers and predicted distribution shifts of Anopheles coluzzii under climate change: Results from the systematic review.

The Science of the total environment·2025
Same author

Neutron capture measurements for s-process nucleosynthesis: A review about CERN n_TOF developments and contributions.

The European physical journal. A, Hadrons and nuclei·2025
Same author

Antiprotons and Elementary Particles over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2025
Same author

Solar Modulation of Cosmic Nuclei over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2025
Same author

AIEC-dependent pathogenic Th17 cell transdifferentiation in Crohn's disease is suppressed by <i>rfaP</i> and <i>ybaT</i> deletion.

Gut microbes·2024
Same journal

A pump-free gravity-driven microfluidic chip for rapid RPA-LFS-based detection of Magnaporthe oryzae AvrPi9 gene.

Biomedical microdevices·2026
Same journal

Mechanotherapeutic biomaterials: Overcoming physical barriers to enhance intratumoral drug delivery in solid tumours.

Biomedical microdevices·2026
Same journal

Reversibly-sealable microfluidic platform for multi-molecule gradient delivery to large adherent cell cultures.

Biomedical microdevices·2026
Same journal

3D printed chip as platform to vascularize hiPSCs-derived kidney organoids.

Biomedical microdevices·2026
Same journal

Ingestible smart capsules: from engineering innovation to GI drug delivery.

Biomedical microdevices·2026
Same journal

An inexpensive, portable, refrigeration-free, ready-to-use microfluidic device for real-time multiplexed molecular detection of HIV, HBV, and HCV.

Biomedical microdevices·2026
See all related articles

Disposable plastic microreactors offer efficient, low-cost solutions for genomic analyses like DNA amplification and real-time quantitative PCR (qPCR). These biocompatible devices may advance point-of-care diagnostics.

Area of Science:

  • Biomedical Engineering
  • Molecular Biology
  • Materials Science

Background:

  • Conventional Polymerase Chain Reaction (PCR) equipment can be expensive and complex.
  • There is a need for efficient, low-cost, and portable solutions for genomic analysis.
  • Advancements in microfluidics and polymer science offer opportunities for novel diagnostic tools.

Purpose of the Study:

  • To design, develop, and assess disposable, fully plastic microreactors for genomic analyses.
  • To evaluate the efficiency and selectivity of these microreactors compared to conventional PCR methods.
  • To explore the potential of these microreactors for point-of-care diagnostics.

Main Methods:

  • Fabrication of disposable, biocompatible, fully plastic microreactors.

More Related Videos

Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

Related Experiment Videos

Last Updated: Jun 20, 2026

Microfluidic Applications for Disposable Diagnostics
10:21

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

Reusable Single Cell for Iterative Epigenomic Analyses
10:28

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
12:04

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

Published on: December 6, 2013

  • Integration of microreactors with reusable hardware for thermal cycling and real-time detection.
  • Assessment of microreactor performance for DNA amplification, quantitative PCR (qPCR), and multiplex PCR.

    • Main Results:

    • Plastic microreactors demonstrated high efficiency and selectivity in DNA amplification and multiplex PCR.
    • Quantitative PCR (qPCR) applications showed successful real-time signal detection.
    • Performance was comparable or superior to conventional laboratory PCR equipment.

    Conclusions:

    • Disposable plastic microreactors are highly efficient for various genomic analyses.
    • Low-cost production and broad applicability suggest potential for point-of-care diagnostics.
    • These biochips could revolutionize accessible molecular diagnostics.