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A physical map of the human PI and AACT genes
L Sefton1, G Kelsey, P Kearney
1Department of Genetics and Biometry, University College London, United Kingdom.
Genomics
|July 1, 1990
Abstract:
We have used probes from the human genes PI, PIL, and AACT (alpha 1-antitrypsin, alpha 1-antitrypsin-related sequence, and alpha 1-antichymotrypsin) to make a pulsed-field map of the surrounding region of 14q31-32. We have discovered that the PI-PIL gene cluster is only 220 kb away from the AACT gene and that it is orientated in the opposite direction. The comparatively short distance between the genes comes as a surprise given previous estimates of the level of genetic recombination between them.