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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

[Comparative analysis on clinical manifestations for gastroenteritis caused by norovirus and rotavirus]

Li Deng1, Li-ying Jia, Yuan Qian

  • 1Department of Infection and Digestion, Affiliated Childrens' Hospital to Capital Institute of Pediatrics, Beijing 100020, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|September 8, 2009
PubMed

Insights

Rotavirus and norovirus cause similar gastroenteritis symptoms in children, with rotavirus peaking in winter. Both are significant causes of acute diarrhea in young children.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Gastroenterology

Background:

  • Gastroenteritis is a common illness in infants and young children.
  • Norovirus and rotavirus are significant viral causes of gastroenteritis worldwide.

Purpose of the Study:

  • To compare clinical manifestations of norovirus and rotavirus gastroenteritis in Beijing infants and young children.
  • To identify differences in seasonality and clinical presentation between the two viruses.

Main Methods:

  • Stool specimens collected from children with acute diarrhea (2002-2006).
  • Polyacrylamide gel electrophoresis (PAGE) for rotavirus detection.
  • Enzyme immunoassay (EIA) for norovirus detection.

Main Results:

  • Rotavirus detected in 33.8% of specimens; norovirus in 24.8%.
  • Clinical symptoms were similar, except for fever.
  • Rotavirus peaked in colder months (October-January); norovirus showed no distinct seasonal peak.

Conclusions:

  • Rotavirus is a primary cause of acute diarrhea in young children.
  • Norovirus is also an important pathogen for gastroenteritis in this age group.
  • Clinical presentations of norovirus and rotavirus gastroenteritis are largely indistinguishable.
Abstract

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