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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
A 2-arylbenzofuran derivative from Hopea mengarawan
Lia D Juliawaty1, Sahidin, Euis H Hakim
1Natural Products Research Group, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
A novel compound, diptoindonesin G, was isolated from Hopea mengarawan bark. This compound demonstrated the strongest cytotoxic activity against murine leukemia P-388 cells among the tested natural products.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Hopea mengarawan bark is a source of bioactive compounds.
- Oligostilbenes and benzofuran derivatives are classes of natural products with potential biological activities.
Purpose of the Study:
- To isolate and characterize compounds from Hopea mengarawan bark.
- To evaluate the cytotoxic potential of isolated compounds against cancer cells.
Main Methods:
- Extraction of Hopea mengarawan tree bark using acetone.
- Isolation and purification of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (2D NMR, HREIMS).
- Cytotoxicity testing against murine leukemia P-388 cell line.
Main Results:
- Isolation of a new 2-arylbenzofuran derivative, diptoindonesin G (1).
- Identification of nine known oligostilbenes.
- Diptoindonesin G (1) exhibited the most potent inhibition of leukemia cell growth.
Conclusions:
- Diptoindonesin G is a novel cytotoxic compound from Hopea mengarawan.
- The study highlights the potential of Hopea mengarawan as a source for anticancer drug discovery.
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