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Published on: December 2, 2015
[Anxious-depressive disorders and metabolic syndrome]
1Centrum preventivní kardiologie II. interní kliniky Lékarské fakulty UK a FN v Plzni. rosolova@fnplzen.cz
Vnitrni Lekarstvi
|September 8, 2009
Summary
Anxiety and depression are linked to metabolic syndrome (MS), nearly doubling the risk. Elevated cortisol in psychiatric patients suggests sympathoadrenal axis involvement in this comorbidity.
Area of Science:
- Psychiatry
- Cardiology
- Endocrinology
Background:
- Anxiety and depressive disorders frequently co-occur with chronic illnesses.
- These conditions are associated with increased cardiometabolic risk and poorer cardiovascular outcomes.
- The link between cardiovascular disease, diabetes, and psychiatric disorders is bidirectional.
Purpose of the Study:
- To investigate the association between depressive disorders and metabolic syndrome (MS).
- To explore the role of the sympathoadrenal axis in the comorbidity of MS and depression.
Main Methods:
- Analysis of data from 1,050 male and female patients from the Pilsen Longitudinal Study III (PILS III).
- Comparison of depressive disorder prevalence and urinary cortisol, catecholamines, and serotonin excretion between patients with and without MS.
- Assessment of associations between psychiatric disorders and MS risk factors.
Main Results:
- Depressive disorders were nearly twice as frequent in patients with MS (RR = 1.85).
- Patients with psychiatric disorders exhibited higher urinary cortisol excretion compared to those without.
- No significant differences were found in catecholamine or serotonin excretion.
Conclusions:
- Findings provide indirect evidence for the sympathoadrenal axis's role in the comorbidity of MS and depression.
- Anxiety and depression should be considered high-risk indicators for atherosclerotic vascular diseases, MS, and type 2 diabetes in primary prevention.
- More rigorous secondary prevention strategies are warranted for patients with anxiety and depression due to their elevated cardiometabolic risk.
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